加味益胃汤治疗原发性干燥综合征的临床观察

Clinical observation on treatment of primary sjogren's syndrome with modified yiwei soup

目的分析原发性干燥综合征应用中药加味益胃汤治疗的效果。方法随机选择2015年3月~2016年5月在本院接受治疗的原发性干燥综合征患者60例参与研究,随机分为两组,对照组利用常规药物对患者进行治疗,观察组在对照组基础上加用中药加味益胃汤治疗,比较两组治疗临床效果。结果观察组治疗总有效率为93.33%,对照组为76.67%,两者比较差异有统计学意义(P<0.05);观察组治疗后SchirmerⅠ试验结果高于对照组,静态唾液流量多于对照组,两组比较差异有统计学意义(P<0.05);观察组治疗后免疫球蛋白IgG、IgM、IgA指标结果均低于对照组,两组比较差异有统计学意义(P<0.05)。结论加味益胃汤用于治疗原发性干燥综合征患者,能够更有效改善临床症状,改善SchirmerⅠ试验结果,增加静态唾液流量,改善免疫球蛋白情况。

Objective To analyze the effect of traditional Chinese medicine Modified Yiwei soup on primary Sjogren＇s syndrome. Methods 60 patients with primary sjogren＇s syndrome who were treated in our hospital from March 2015 to May 2015 were randomly divided into two groups. The control group was treated with conventional drugs. The observation group was treated with Chinese medicine modified yiwei soup based on the treatment of the control group. And the clinical effect between the two groups was compared. Results The total effective rate of treatment was 93.33% in the observation group and 76.67% in the control group. The difference between the two groups was statistically significant（P 〈0.05）. After treatment, the Schirmer Ⅰ test results and the static saliva flow in the observation group were higher than those in the control group,and the difference between the two groups was statistically significant（P〈0.05）. The results of immunoglobulin IgG, IgM and IgA in the observation group were lower than those in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Modified Yiyi soup for the treatment of patients with primary sjogren＇s syndrome can improve clinical symptoms and Schirmer Ⅰ test results, increase static saliva flow and improve immunoglobulin.