PNPLA3基因多态性与HBV感染易感性的关联性分析

Association analysis between PNPLA3 gene polymorphism and susceptibility to HBV infection

目的探讨PNPLA3基因多态性(rs738408、rs738409、rs2294918、rs2294919和rs2281135)与乙型肝炎病毒(hepatitis B virus vaccine,HBV)慢性感染的相关性。方法采用病例对照研究方法,对符合纳入条件的HBV慢性感染(病例组)1 792例,HBV慢性未感染(对照组)618例,采用χ2检验、多重Logistic回归分析等统计方法分析PNPLA3基因多个SNP位点与HBV感染易感性的关联性。结果在控制了性别、年龄、吸烟和饮酒因素后,携带PNPLA3rs738408TC或TT基因型的个体感染HBV的风险降低,OR值分别为0.059和0.020(95%CI=0.028~0.125,P<0.001;95%CI=0.007~0.053,P<0.001);携带PNPLA3rs738409GG基因型的个体感染HBV的可能性为PNPLA3rs738409CC基因型携带者的27.550倍(95%CI=10.024~75.718,P<0.001);携带PNPLA3rs2294918AA基因型的个体感染HBV的风险降低,OR值为0.354(95%CI=0.210~0.599,P<0.001);携带PNPLA3rs2294919 TC基因型的个体感染HBV的风险降低,OR值为0.598(95%CI=0.429~0.833,P=0.002)。结论 PNPLA3rs738408 TC或TT基因型、rs738409 GG基因型、rs2294918 AA基因型和rs2294919TC基因型均与HBV感染有关。

Objective To investigate the association of PNPLA3 gene polymorphisms （rs738408,rs738409,rs2294918,rs2294919 and rs2281135） with chronic infection of hepatitis B virus vaccine（HBV）.Methods Case control study was used.For chronic HBV infection in line with the conditions included （case group） 1 792 cases,chronic HBV infection （control group） 618 cases,the association between multiple SNP loci of PNPLA3 gene and susceptibility to HBV infection was analyzed by statistical methods such as test and multiple Logistic regression analysis.Results The subjects with the PNPLA3 rs738408 TC/TT genotype might have lower risk of HBV infection（OR=0.059,95% CI=0.028-0.125,P〈0.001 for TC;OR=0.020,95%CI=0.007-0.053,P〈0.001 for TT）,the subjects with rs738409 GG genotype had a 27.550（95% CI=10.024-75.718,P〈0.001） times higher odds of HBV infection.rs2294918 AA genotype might reduce the risk of HBV infection（OR=0.354,95% CI=0.210-0.599,P〈0.001）.rs2294919 TC genotype had a 0.598 （95% CI=0.429-0.833,P=0.002） times lower odds of HBV infection.The results mentioned above were adjusted by sex,age,smoke and drink values.Conclusion There was significant relationship between PNPLA3 gene polymorphisms（rs738408 TC or TT,rs738409 GG,rs2294918 AA and rs2294919 TC） and HBV infection.