坏疽性脓皮病

Pyoderm a Gangrenosum

坏疽性脓皮病(pyoderma gangrenosum,PG)是一种少见的中性粒细胞性皮病,表现为迅速发展的红斑、糜烂、溃疡,常伴有发热及剧烈疼痛。其病因及发病机制未明,可与遗传因素、中性粒细胞功能失调和异常炎症反应相关。临床可表现为急性或慢性发展,分为多个亚型,且常合并潜在的系统性疾病。本病难诊断,易误诊,且尚无诊疗金标准。治疗主要包括局部治疗、系统治疗及潜在疾病的治疗。

Pyoderma gangrenosum（ PG） is a rare neutrophilic dermatosis,characterized by erythema,erosion and painful,necrotic ulceration. Pathogenesis of PG is not fully addressed,Genetic background,neutrophil dysfuction and abnormal inflammation have been reported. PG can develop rapidly or chronicly,and there are many clinical variants. It is associated with underlying disease. PG is difficult to diagnose and there is no gold standard of treatment. The management of PG include topical treatments,systemic medicine and the treatments of underlying disease as well.