活化白细胞粘附分子在卵巢浆液性肿瘤中的表达及意义

The expression of activated leukocyte cell adhesion molecule in ovarian epithelial tumors and its correlation with prognosis

目的探讨活化白细胞粘附分子(ALCAM)在卵巢浆液性肿瘤中的表达及其意义。方法使用免疫组化法检测ALCAM在卵巢良性、交界性及恶性浆液性性肿瘤病灶中的表达。使用Elisa检测卵巢肿瘤患者术前血清中ALCAM浓度。结果卵巢良性、交界及恶性浆液性肿瘤患者血清均可检测到ALCAM,三组间浓度无统计学差异。ALCAM在卵巢良性、交界性、恶性肿瘤中的阳性表达率分别为:31.8%、28.5%及62.2%。良性与恶性肿瘤组间ALCAM蛋白表达率差异有统计学意义(P=0.001)。卵巢恶性肿瘤组织中ALCAM蛋白的表达与手术分期、是否有淋巴结转移及预后有相关性。ALCAM阳性组卵巢恶性肿瘤患者5年生存率为23.5%,而ALCAM阴性组为50.0%,二者之间差异有统计学意义(P=0.02)。结论卵巢恶性肿瘤组织中ALCAM表达增强为卵巢恶性肿瘤不良预后的指标。

Objective To investigate the expression of activated leukocyte cell adhesion molecule （ALCAM） in ovarian epithelial tumor and its correlation with prognosis. Methods The expression of ALCAM were detected in malignant, borderline and benign ovarian epithelial tumor tissues by immunohistochemical method. The serum concentration of ALCAM in patients with ovarian epithelial tumors before surgery were detected by Elisa assay. Kaplan-Meier method was used to analyse the correlation between the expression of ALCAM and prognosis of malignant ovarian epithelial tumor. Results ALCAM were detected in the serum of the patient with malignant, borderline or benign ovarian epithelial tumors. There was no difference between them. The expression rates of ALCAM were 31.8%, 28.5% and 62.2% in benign tumor, borderline tumor and malignant ovarian epithelial tumor tissues respectively. There was statistic difference between theexpression rates of ALCAM in malignant and benign tumors （P = 0.001）. There were correlation between the expression of ALCAM with clinical staging, lymph node metastasis and prognosis of malignant ovarian epithelial tumor. The five year survival rate was 23.5 % in malignant ovarian epithelial tumor patients with positive ALCAM expression, and 50.0% in patients with negative ALCAM expression. Conclusion ALCAM could be a prognosis factor for malignant ovarian epithelial tumor.