参苓白术散改善晚期肿瘤患者生活质量的近期临床观察

Recent clinical observation on improvement of life quality of the advanced tumor patients by Shenlingbaizhu powder

目的:观察参苓白术散在改善晚期肿瘤患者生活质量方面的作用。方法:将60例诊断符合恶性肿瘤TNM分期Ⅳ期,辩证属于脾气虚型患者,随机分为2组。对照组30例予以营养支持治疗;治疗组30例,加用参苓白术散,水煎服,每日1剂,分2次温服,共用4周。观察治疗前后临床证候、体质量、生存质量评定(kanrofsky score,KPS)、外周血象[白细胞(white blood cell,WBC),血红蛋白(hemoglobin,Hb),血清前白蛋白(prealbumin,PAB)]情况。结果:2组治疗后比较,在以体倦乏力、食少纳呆、大便异常、腹胀等为主症的中医证候总有效率分别为92.9%和70.8%,治疗组明显优于对照组(P<0.05)。KPS评分,治疗组在治疗后有显著提高(P<0.05),治疗后治疗组KPS评分较对照组高(P<0.05)。治疗后,治疗组WBC有明显提升(P<0.05),且较对照组明显升高(P<0.05)。结论:参苓白术散可改善晚期恶性肿瘤患者的部分临床症状,在一定程度上提高生活质量,值得临床推广。

Objective：To observe the effect of Shenlingbaizhu powder on improvement of the life quality. Methods：Sixty advanced tumor patients were randomized into treatment group and control group,with thirty in each. The control group was given compound amino acid injection and the treatment group was given Shenlingbaizhu powder in addition. The effect was evaluated after 4 weeks. The clinical symptoms,body weight,kanrofsky score（KPS）,white blood cell（WBC）,hemoglobin（Hb） and prealbumin（PAB） were observed.Results：After treatment,the fatigue,the total effective rate of the Chinese medicine symptom in treatment group and control group were 92.9% and 70.8% respectively,with significant differences between groups（P〈0.05）. After treatment,the KPS score was improved in treatment group（P〈0.05）and improved significantly in treatment group than in control group（P〈0.05）. After treatment,the WBC was improved in treatment group（P〈0.05）. Conclusion：Shenlingbaizhu powder can improve life quality of the patient with advanced tumor.