鼠神经生长因子治疗老年人脑出血的疗效及对神经功能的影响

Effect of nerve growth factor in the treatment of elderly patients with cerebral hemorrhage and its effect on the nervous function

目的 探讨鼠神经生长因子治疗老年人脑出血的临床疗效及其对神经功能的影响.方法 选择老年脑出血患者90例,采用随机数字表法分为观察组和对照组,每组45例,对照组实行常规的脑出血治疗,观察组在对照组的基础上同时注射鼠神经生长因子.比较两组治疗后的疗效,分析两组治疗前后神经功能缺损（NIHSS）评分和简式Fugl-Meyer运动功能（FMA）评分的变化.结果 观察组总有效率为93.33%,明显高于对照组的73.33%,差异有统计学意义（χ2=6.480,P=0.010）;两组治疗前NIHSS评分差异无统计学意义（t=0.333,P=0.739）;治疗后观察组NIHSS评分为（6.49±7.02）分,对照组为（11.01±8.65）分,观察组治疗后的NIHSS评分低于对照组,差异有统计学意义（t=2.721,P=0.007）;两组治疗前FMA评分差异无统计学意义（t=0.198,P=0.198）;治疗后观察组FMA评分高于对照组,差异有统计学意义（t=3.222,P=0.001）.结论 老年脑出血患者应用鼠神经生长因子治疗,能够有效地改善患者神经功能缺损和日常生活活动能力,临床疗效显著,值得临床推广应用.

Objective To investigate the effect of nerve growth factor in the treatment of senile cerebral hemorrhage and its effect on the nerve function.Methods According to the digital table,90 elderly patients with cerebral hemorrhage were randomly divided into observation group and control group,45 patients in each group.The control group was given conventional treatment for cerebral hemorrhage.The observation group was injected mouse nerve growth factor based on the control group.The efficacy of the two groups after treatment,nerve function defect score（NIHSS） before and after treatment changes and simple type Fugl-Meyer motor function score（FMA） were compared.Results The total effective rate of the observation group after treatment was 93.33%,which was higher than 73.33% of the control group,the difference was statistically significant（χ2=6.480,P=0.010）.Before treatment,the NIHSS scores of the two groups had no statistically significant difference （t=0.333,P=0.739）.After treatment,the NIHSS score of the observation group was （6.49±7.02）points,which was lower than （11.01±8.65）points of the control group,the difference was statistically significant（t=2.721,P=0.007）.Before treatment,the FMA scores of the two groups had no statistically significant difference （t=0.198,P=0.198）.Compared with the control group,the FMA score of the observation group after treatment was significantly higher,the difference was statistically significant（t=3.222,P=0.001）.Conclusion Rat nerve growth factor in the treatment of elderly patients with cerebral hemorrhage can effectively improve the patients＇ neurological deficits and activities of daily living,the clinical efficacy is significant,it is worthy of clinical application.