益气养阴方联合奥美拉唑治疗慢性萎缩性胃炎疗效观察

Observation of the curative efficacy of Yiqi Yangyin formula in combination with omeprazole in the treatment of patients with chronic atrophic gastritis

目的 观察益气养阴方联合奥美拉唑治疗慢性萎缩性胃炎（CAG）的疗效及对患者血清表皮生长因子（EGF）水平的影响.方法 收集104例CAG患者为研究对象,采用随机数字表法分为对照组（52例）和观察组（52例）.患者均给予常规治疗,在此基础上,对照组给予奥美拉唑治疗,观察组在对照组基础上联合应用益气养阴方治疗,疗程均为6周.疗程结束后,比较两组临床疗效,上腹胀痛、嗳气、反酸、恶心等临床症状改善情况及血清EGF水平.结果 观察组总有效率为94.2%,高于对照组的80.8%,两组差异有统计学意义（χ2=4.308,P〈0.05）.治疗后,观察组上腹胀痛、嗳气、反酸及恶心发生率均显著低于对照组（57.7%比76.9%、53.8%比75.0%、50.0%比73.1%、46.2%比71.2%,χ2=4.370、5.076、5.850、6.701,均P〈0.05）.观察组血清EGF水平明显低于对照组[（1.47±0.30）μg/L比（2.01±0.35）μg/L）,t=8.45,P〈0.05）],两组差异有统计学意义.结论 益气养阴方联合奥美拉唑治疗CAG疗效良好,有效率高,能够显著改善患者的临床症状及降低血清EGF水平.

Objective To observe and analyze the curative efficacy of Yiqi Yangyin formula in combination with omeprazole in the treatment of patients with chronic atrophic gastritis （CAG）,and its effects on serum epidermal growth factor （EGF）.Methods 104 patients with CAG were collected as research subjects.And they were randomly divided into two groups equally.All patients were given conventional treatment for 6 months.Besides that,the control group was treated with omeprazole,and the observation group was treated with Yiqi Yangyin formula in combination with omeprazole for 6 months.After treatment,the curative efficacy of CAG,rate of pain,belching,acid reflux,nausea and levels of serum EGF were compared between the two groups.Results The effective rate of the observation group was higher than that in the control group （94.2% vs 80.8%,χ2=4.308,P〈0.05）.In comparison with the control group after treatment,the observation group had lower incidence of upper abdominal distention and pain,eructation,acid regurgitation,nausea （57.7% vs 76.9%,53.8% vs 75.0%,50.0% vs 73.1%,46.2% vs 71.2%,χ2=4.370,5.076,5.850,6.701,all P〈0.05）,and lower level of serum EGF[（1.47±0.30）μg/L vs （2.01±0.35）μg/L）,t=8.45,P〈0.05].Conclusion Yiqi Yangyin formula in combination with omeprazole is effective for CAG with a high effective rate.And it can significantly improve clinical symptoms and reduce level of serum EGF.