帕金森病患者的体质量变化及其相关因素分析

Analysis of weight change and its related factors of Parkinson's disease patients

目的:研究帕金森病(Parkinson’s disease,PD)患者体质量变化及相关影响因素。方法:自2015年1月至2015年10月,选取江苏省人民医院PD专病门诊共122名PD患者应用体质量测量仪、统一帕金森病评分量表(unified Parkinson’s disease rating scale,UPDRS)、Hoehn-Yahr分级(H-Y分级)、PD生活质量问卷调查(Parkinson’s disease questionnaire,PDQ-39)以及PD非运动症状评估量表(non-motor symptoms score,NMSS),评估PD患者体质量变化及相关影响因素,以同时期门诊健康体检人员共100例作为对照,对研究数据采取独立样本的t检验及多元线性回归分析。结果:PD患者人体质指数(body mass index,BMI)较正常人群有明显的下降(t=3.999,P=0.000),且以脂肪量丢失为主;女性PD患者出现体质量丢失的风险更高;H-Y分级≥2.5的PD患者体质量下降更加明显。结论:PD病人的BMI较健康对照人群有明显的下降,女性PD患者有更高的风险出现体质量丢失;PD患者中H-Y分级≥2.5的人群更易出现体质量丢失。

Objective：To study the changes in body weight and related factors of Parkinson＇s disease（PD）patients. Methods：One hundred and twenty-two PD patients,selected from PD Special Disease Clinic of Jiangsu Province People＇s Hospital from January 2015 to October 2015,were measured by weight measuring instrument,unified Parkinson disease rate scale（UPDRS）,Hoehn-Yahr grading（H-Y）,Parkinson disease questionnaire（PDQ-39）and non-motor symptoms score（NMSS）to assess weight changes and related clinical data. A total of 100 cases outpatient medical personnel of the same period were chosen as control. Independent samples t test,and multiple linear regression analysis of data were used. Results：Body mass index（BMI）of PD patients had a significant decline compared with that of healthy adults（t=3.999,P=0.000）,mainly in fat loss.Female PD patients had a higher risk of weight loss. H-Y≥2.5 PD patients had more obvious weight loss. Conclusion：BMI reduces more evidently in PD patients than in controls. Female PD patients have a higher risk of weight loss. PD patients with H-Y≥2.5 are more prone to weight loss.