骨代谢相关因子与非酒精性脂肪肝病研究进展

Research progress of bone metabolism related factors and nonalcoholic fatty liver disease

肝脏是脂质代谢的重要器官,肝中过量的脂质堆积诱导细胞内大量活性氧的生成,引起肝细胞内质网应激、线粒体功能紊乱及脂毒性,这与非酒精性脂肪肝病发生密切相关。非酒精性脂肪肝病除引起肝脏病变及死亡外,还与2型糖尿病、动脉硬化性心脑肾血管疾病及肝外恶性肿瘤密切相关。近年来研究发现骨质疏松、骨密度减低与非酒精性脂肪肝病之间有一定的相关性,一些骨代谢相关因子在非酒精性脂肪肝病不同阶段存在异常,本文主要就骨桥蛋白、骨保护素、骨形成蛋白、骨硬化蛋白及骨膜蛋白与非酒精性脂肪肝病之间关系研究进展进行综述。

The liver is an important organ in the lipid metabolism,excessive lipid accumulation in the liver induces the production of reactive oxygen species,leading to endoplasmic reticulum stress, mitochondrial dysfunction and lipid toxicity, which is closely related to non-alcoholic fatty liver disease（NAFLD）. NAFLD is not only associated with liver disease and death, but also closely related to type 2 diabetes, atherosclerotic cardiocerebral vascular disease and extrahepatic malignant tumor. Recent studies have found that osteo- porosis,bone density has certain correlation with NAFLD;some factors of bone metabolism are abnormal in different stages of NAFLD. In this paper,we will review the relationship between these factors （osteopontin, osteoprotegerin and bone morphogenetic pro- tein, bone sclerosis and periosteal protein protein） and NAFLD.