腹腔镜手术联合GnRH-a治疗子宫内膜异位症对照观察

A control study of laparoscopic operation plus GnRH-a in the treatment of endometriosis

目的 观察腹腔镜手术联合促性腺激素释放激素激动剂治疗子宫内膜异位症的临床疗效. 方法 将110例子宫内膜异位症患者按随机数字表法分为两组,每组55例.两组均行腹腔镜手术治疗,观察组在此基础上联合醋酸亮丙瑞林微球治疗,治疗3个月,随访24个月.比较两组治疗总有效率、随访24个月的复发率及已婚患者妊娠率.结果 治疗3个月观察组总有效率为92.7%,对照组为72.7%,观察组显著高于对照组（P〈0.05）.观察组复发率、已婚患者妊娠率均显著高于对照组（P〈0.05或0.01）.结论 腹腔镜手术联合促性腺激素释放激素激动剂治疗子宫内膜异位症疗效显著,且优于单用腹腔镜手术治疗.

Objective To observe the efficacy of laparoscopic operation plus GnRH-a in the treatment of endometriosis.Methods A total of 110 endometriosis patients were randomly divided into two groups of 55 ones each.Both groups received laparoscopic operation, on this basis observation group was plus leuprorelin acetate for 3 months, and followed up for 24 months.Total effective rates, relapse rates within 24 month follow-up and pregnancy rates of the married were compared between 2 groups.Results After 3 month treatment total effective rate （92.7% vs.72.7%, P〈0.05） as well as relapse and pregnancy rate （P〈0.05 or 0.01） were significantly higher in observation than in control group.Conclusion Laparoscopic operation plus GnRH-a has an evident effect compared with single laparoscopic operation in the treatment of endometriosis.