食管鳞癌患者凝血指标与临床病理特征的关系

Relationships between coagulation indicators and clinicopathological characteristics of patients with esophageal squamous-cell carcinoma

目的探讨观察食管鳞癌患者凝血指标与临床病理特征的关系。方法选择44例食管鳞癌患者作为食管鳞癌组,另选35例健康体检者作为对照组。对比两组凝血指标[血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)]水平,分析食管鳞癌患者PLT、PT、APTT、FIB、D-D水平与临床病理特征的关系。结果与对照组相比,食管鳞癌组PLT、PT、FIB、D-D水平高(P均<0.05)。食管鳞癌患者PLT、PT、APTT、FIB、D-D水平与性别、年龄、淋巴结转移状态无相关性。有血栓史、远处转移者FIB水平高于无血栓史、无远处转移者(P均<0.05);PLT、PT、APTT、D-D水平与血栓史、远处转移状态无相关性。Ⅲ~Ⅳ期者FIB、D-D水平高于Ⅰ~Ⅱ期者(P<0.05),PLT、PT、APTT水平与TNM分期无相关性。结论食管鳞癌患者存在高凝状态,有血栓史以及TNM分期较晚且存在远处转移的患者更易出现高凝状态。

Objective To observe the relationships between coagulation indicators and clinicopathological characteristics of patients with esophageal squamous-cell carcinoma. Methods Forty-four hospitalized patients with esophageal squamous-cell carcinoma（ esophageal squamous-cell carcinoma group） and 35 cases of healthy people（ control group） were selected. We compared the coagulation indicators,including platelets（ PLT）,prothrombin time（ PT）,activated partial prothrombin time（ APTT）,fibrinogen（ FIB）,and D-dimer（ D-D）,to analyze the correlations between coagulation indicators and clinicopathological characteristics. Results Compared with the control group,the levels of PLT,PT,FIB,and D-D in esophageal squamous-cell carcinoma group were significantly higher（ all P 〈0. 05）. The levels of PLT,PT,APTT,FIB,and D-D were not correlated with gender,age,and lymph node metastasis in patients with esophageal squamous-cell carcinoma. The FIB level of patients with thrombus history and distant metastasis was significantly higher than that in patients with no thrombus history or distant metastasis（ P 〈0. 05）. The levels of PLT,PT,APTT,and D-D had no correlation with thrombus history and distant metastasis status. The levels of FIB and D-D of patients in Ⅲ-Ⅳ stage were significantly higher than those of patients in Ⅰ-Ⅱ stage（ P 〈0. 05）,and the levels of PLT,PT,and APTT were not correlated with TNM stage. Conclusion Patients with esophageal squamous-cell carcinoma have hypercoagulative state,and it is more significant in patients with history of thrombosis and distant metastasis at advanced TNM stages.