半乳糖凝集素-3与巨噬细胞炎性反应的关系

Relationship between galectin-3 and macrophage in inflammation reactions

半乳糖凝集素-3(Galectin-3,Gal-3)是一种30 kDa左右且高度保守的β-半乳糖蛋白,在人体各组织及微环境内广泛存在.由于Gal-3特有的糖识别结构域和高度保守的N-端结构域,使其具有可塑性强和功能多样化的特点,并在人体内作为特殊中介物参与炎症反应.巨噬细胞作为主要的炎性反应细胞对调节炎症反应起关键作用.主要介绍Gal-3作为炎性细胞因子在炎症中与巨噬细胞的关系及研究进展.

Galectin-3 （Gal-3） is an approximately 30 kDa and highly conserved β-galactose distributed in a wide range of tissues and microenvironments. Its specific carbohydraterecognition domain and evolutionary conserved N-terminal domain of Gal-3 make it more flexible and multifunctional as a mediator affecting inflammation. Macrophage plays an important role in inflammatory reactions as a major immunocyte. This review focuses on the relationship between Gal-3 and macrophage in inflammatory reactions.