高危型人乳头瘤病毒与液基细胞学检测在宫颈疾病筛查中应用研究

Application Study on High-Risk Human Papilloma Virus and Thinprep Cytology Test in Cervical Disease Screening

目的分析高危型人乳头瘤病毒与液基细胞学检测在宫颈疾病筛查中的应用。方法选取2015年8月~2016年6月在我院就诊的2500例宫颈疾病患者,分别采用HPV与TCT对宫颈疾病患者进行检测。结果不同病变类型中TCT和HR-HPV DNA阳性率随病变程度的升高而上升,差异显著(P<0.05);两种方法联合检测检测率高于单独病理检测,差异显著(P<0.05)。结论 TCT和HR-HPV DNA联合检测可有效提高HPV检出率,应用于宫颈疾病筛查中可有效提高患者治疗成功率,大大降低了漏诊率,在临床应用中值得推广。

Objective To analyze the application of high-risk human papilloma virus（HPV）and thinprepcytology test（TCT）in cervical disease screening. Methods 2500 patients with cervical diseases treated inthe hospital from August 2015 to June 2016 were selected, and they were inspected respectively by HPVand TCT. Results The TCT and the positive rate of HR-HPV DNA in different types of lesions rose asthe degree of lesions increased, with statistical difference （p〈0.05）; The detection rate of two kinds oftests was higher than pure pathological detection, with statistical difference （P〈0.05）. Conclusion Thecombined detection of TCT and HR-HPV DNA can effectively improve detection rate of HPV, improvethe success rate in cervical disease screening and greatly decrease the rate of missed diagnosis, which isworthy of generalization in clinical application.