壮医药线点灸对带状疱疹患者临床疗效及血清Th细胞因子的影响

Clinical Efficacy of Minority-Zhuang's Drug Soaked Line Pointed Moxibustion Therapy in treating Patients with Herpes Zoster and Its effectson Serum-Th Cytokines

目的探讨壮医药线点灸对带状疱疹患者临床疗效及血清Th细胞因子的影响。方法带状疱疹患者80例,随机分成A、B组,40例/组。A组给予口服泛昔洛韦3次/d,0.25 g/次,实施壮医药线点灸,1次/d。B组仅给予口服泛昔洛韦3次/d,0.25 g/次。10d后比较2组患者临床疗效及治疗前后血清IL-2,IL-4和TNF-α水平变化。结果2组临床有效率分别为77.5%、52.5%,差异有统计学意义(P<0.05);2组治疗前血清IL-2,IL-4和TNF-α差异无统计学意义。A组治疗前后血清IL-2,IL-4和TNF-α差异有统计学意义(P<0.05),B组治疗前后血清IL-2,IL-4和TNF-α差异有统计学意义(P<0.05)。2组在治疗后相比,血清IL-2,IL-4和TNF-α差异有统计学意义(P<0.05)。结论壮医药线点灸联合泛昔洛韦治疗带状疱疹能够提高疗效,并能改善患者血清Th细胞因子水平。

Objective In order to investigate the clinical efficacy of Minority-Zhuang＇s drug soaked line pointed moxibustion therapy in treating patients with herpes zoster and its effects on serum-Th cytokines. Methods Eighty cases of herpes zoster patients were randomly divided into group A and group B, and 40 cases in each group. Group A was given famciclovir orallythree times a day and 0.25 g one time, with Minority-Zhuang＇s drug soaked line pointed moxibustion therapy once a day. Group B was only given famciclovir orally three times a day and 0.25 g one time. After 10 days, the levels of serum IL-2, IL-4 and TNF-α and clinical efficacy of two groups were compared before and after treatment. Results The clinical effective rates of the two groups were 77.5% and 52.5%. The differences were statistically significant （P〈0.05）. There were no statistical significances of the differences of serum IL-2, IL- 4 and TNF-α between the two groups. The differences of serum IL-2, IL-4 and TNF-α before and after 10 days treatment of group A were statistically significant （P〈0.05）. The differences of serum IL-2, IL-4 and TNF-α before and after 10 days treatment of group B were statistically significant （P〈0.05）. There was statistical significance of serum IL-2, IL-4 and TNF-α between the two groups after treatment （P〈0.05）. Conclusion The therapy of Minority-Zhuang＇s drug soaked line pointed moxibustion with famciclovir can improve the efficacy in treating herpes zoster, and improve the levels of serum Th cytokine in patients.