辣木叶提取物降低高尿酸血症小鼠尿酸水平及机理研究

Study on Extract of Moringa oleifera Leaves Reducing the Level of Uric Acid in Hyperuricemia Mice and Its Mechanism

[目的]研究辣木叶醇提物对血清尿酸(UA)、肌酐(Cre)、血尿素氮(Bun)、腺苷脱氨酶(ADA)以及肝脏黄嘌呤氧化酶(XOD)的影响。[方法]连续7 d灌胃给予辣木叶醇提物和别嘌呤醇(0.01 g/kg),诱导小鼠产生高尿酸血症,对比各组小鼠血清中UA、Cre、Bun、XOD和ADA的含量变化。[结果]与模型组比较,辣木叶提取物的低、中、高剂量组(1.0、2.0、4.0 g/kg)均可降低高尿酸血症小鼠UA、Cre、Bun、ADA、XOD的水平。[结论]辣木叶醇提物具有降尿酸作用,抑制XOD活性是其降低高尿酸血症小鼠血清尿酸水平的机制之一。

[Objective] The research aimed to study the effect of M. oleifera leave extract（ MOLE） on the level of serum uric acid（ UA）,creatinine（ Cre）,blood usea nitrogen（ Bun）,adenosine deaminase（ ADA） and liver xanthine oxidase（ XOD）. [Method]Intragastric administration of MOLE（ 1. 0,2. 0,4. 0 g/kg） and allopurinol（ 0. 01 g/kg） for 7 days,the level of UA,Cre,XOD and Bun in hyperuricemia mice induced by potassium oxonate was respectively analyzed.[Result]Compared with model group,each dosage group could degrade the levels of serum UA,Cre,Bun,ADA and XOD activities in hyperuricemia mice.[Conclusion]The MOLE could obviously reduce the level of serum uric acid,and the effect is related to its inhibition of hepatic XOD activities.