α-硫辛酸联合莫沙必利治疗糖尿病胃轻瘫的临床疗效观察

Clinical effect of alpha lipoic acid combined with mosapride on the treatment of diabetic gastroparesis

目的探讨α-硫辛酸联合莫沙必利治疗糖尿病胃轻瘫的临床疗效。方法选取2013-05~2015-06该院就诊的糖尿病胃轻瘫患者70例,随机分为观察组和对照组各35例。在治疗糖尿病的基础上,对照组给予口服莫沙必利,观察组给予α-硫辛酸联合莫沙必利治疗,疗程均为14 d,对比分析两组患者的临床治疗效果。结果两组患者治疗前的胃动素水平及胃排空率对比差异无统计学意义(P>0.05)。治疗后两组患者的胃动素水平均比治疗前明显下降,胃排空率均比治疗前明显增高;且观察组的胃动素水平显著低于对照组,胃排空率高于对照组,差异有统计学意义(P<0.05)。观察组患者显效20例,有效13例,无效2例。对照组显效14例,有效12例,无效9例。观察组的疗效明显优于对照组(P<0.05)。结论α-硫辛酸联合莫沙必利治疗糖尿病胃轻瘫临床疗效较好,有效调节胃肠激素,增强患者的胃排空率,降低胃动素水平,改善患者糖尿病胃轻瘫症状,提高患者的生存质量,值得在临床上广泛应用。

Objective To investigate the clinical effect of alpha lipoic acid combined with mosapride on the treatment of diabetic gastroparesis. Methods 70 diabetic gastroparesis patients in our hospital were randomly divided into the observation group and the control group, with 35 cases in each group. In addition to usual anti-diabetic treat- ment, the control group was treated with oral mosapride and the observation group was treated with alpha lipoic acid combined with mosapride for 14 days. The elinieal effects were compared between the two groups. Results There were no significant differences in the levels of motilin and gastric emptying rate between the two groups before treat- ment（ P 〉 0. 05 ）. After treatment, the levels of motilin were significantly decreased and the gastric emptying rates in both of the two groups were significantly higher than those before treatment. The level of motilin in the observation group was significantly lower than that in the control group, whereas the gastric emptying rate of the observation group was significantly higher than that of the control group （ P 〈 0. 01 ）. In the observation group, the clinical effect was markedly effective in 20 cases, effective in 13 cases, ineffective in 2 cases. In the control group, the clinical effect was markedly effective in 14 cases, effective in 12 cases, and ineffective in 9 cases. The clinical effect of the obser- vation group was significantly better than that of the control group （ P 〈 0. 05 ）. Conclusion Alpha lipoic acid combined with mosapride is effective in the treatment of diabetic gastroparesis, which effectively regulates gastrointestinal hormones, enhances the gastric emptying rate, reduces the level of motilin, and improves the symptoms and the qual- ity of life of the patients.