摘要
基质细胞衍生因子-1(stromal cell derived factor-1,SDF-1)属于趋化因子家族,与其受体CXCR4组成SDF-1/CXCR4轴,可以调节间充质干细胞(mesenchymal stem cell,MSC)促进慢性创伤的愈合。慢性创伤包括糖尿病足溃疡、动静脉溃疡、压力性溃疡等。利用SDF-1/CXCR4轴调节MSC向慢性创伤部位归巢促进愈合的特点,可以作为一种有潜力的治疗糖尿病足等慢性创伤的手段,该文主要对SDF-1/CXCR4轴调节MSC的作用机制和信号通路进行综述。
Stromal cell derived factor-1 （SDF-1） belongs to the family of chemokines. SDF-1/CXCR4 axis plays an important role in mesenchymal stem cell homing to chronic wound healing and it can be a potential treatment for the diabetic patients with chronic wounds including diabetic foot ulcer, venous ulcer, arterial ulcer and stress ulcer. This review summarizes the research progress in the mechanism and signaling pathways of SDF-1/CXCR4 axis in regulation of mesenchymal stem cell.
出处
《中国临床新医学》
2017年第6期596-599,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广西自然科学基金资助项目(编号:2013GXNSFAA278002)
