津力达颗粒对糖尿病前期患者血清nesfatin-1与胰岛β细胞功能影响

Effect of Jinlida granule on serum nesfatin-1 level and islet β cell function in patients with pre-diabetes

目的观察津力达颗粒对糖尿病前期患者血清nesfatin-1水平及胰岛β细胞功能影响。方法选取2015年1月—2016年2月石家庄市第一医院内分泌科诊治糖尿病前期患者60例,按随机数字表法分为观察组和对照组各30例。对照组给予饮食及运动治疗,观察组在饮食及运动基础上加用津力达颗粒口服,疗程均12周。比较2组治疗前后血清nesfatin-1水平及各项糖脂代谢的临床指标变化,评估胰岛β细胞功能。结果治疗后,观察组总有效率高于对照组(80.0%vs.46.7%,x^2=7.177,P:0.007),观察组nesfatin-1、2 h PG、HbA_(1c)、FINs、HOMA-IR、BMI较对照组降低(t=2.002、2.771、3.216、2.198、2.279、2.675,P<0.05或P<0.01)。2组FPG、SBP、DBP、TC、TG、HDI-C、LDL-C比较无显著变化(t=1.432、0.221、0.086、0.593、0.881、1.168、1.556,P>0.05)。结论津立达颗粒可纠正糖尿病前期患者糖代谢紊乱,血清nesfatin-1水平下降,有效改善胰岛β细胞功能。

Objective To observe the effect of Jinlida granule on serum nesfatin-1 level and islet fi cell function in treating patients with pre-diabetes.Methods Sixty of pre-diabetes patients were randomly divided into 2 groups,30 case in control group and 30 case in the observation group.Control group received diet and exercise therapy;the observation group therapy based on diet and exercise plus Jinlida granule treatment for 12 weeks.Before and 12 weeks after treatment,compared of the two groups nesfatin 1 and indicators of change.Results After treatment,the total effective rate of observation group was higher than the control group（80.0%vs.46.7%,x^2= 7.177,P =0.007）.The observation group patients serum nesfatin-1,2hPG,HbA_（1c）,FINs,HOMA-IR and BMI levels were lower than the control group（t =2.002,P =0.048;t=2.771,P =0.007;t =3.216,P =0.002;t =2.198,P =0.030;t =2.279,P =0.048;t =2.675,P =0.009）;while the FPG,SBP,DBP,TC,TG,HDL-C and LDL-C levels of patients after treatment in the 2 groups had no significant change（t =1.432,P =0.155;t =0.221,P =0.825;t =0.086,P =0.933;t =0.593,P =0.554;t=0.881,P =0.380;t=1.168,P =0.246;t = 1.556,P =0.122）.Conclusion It demonstrated that the Jinlida granule could correct the disorder of glucose metabolism in patients with pre-diabetes,decrease the level of serum nesfatin-1,and effectively improve the function of islet beta cells.