叶酸及日光浴对老年H型高血压患者血清同型半胱氨酸和血压水平的影响

Effects of folic acid and sun bath on serum homocysteine and blood pressure level in elderly H-type hypertension

目的探讨叶酸及日光浴对老年H型高血压血清同型半胱氨酸(Hcy)和血压水平的影响。方法入选老年轻中度H型高血压患者150例,随机分成对照组、干预组、联合组3组。对照组给予高血压常规治疗;干预组在常规治疗的基础上,给予口服叶酸片5mg/d;联合组在常规降压治疗和口服叶酸片5mg/d的基础上,每天日光浴30min;3组均在治疗前和治疗12周后测量血压和检测血清Hcy水平。结果与治疗前相比,治疗12周后3组的收缩压和舒张压均明显降低(P<0.05),干预组和联合组的血清Hcy水平均明显降低(P<0.05),而对照组的血清Hcy水平无明显变化(P>0.05)。治疗12周后3个组相比较,联合组血压和血清Hcy水平均明显低于干预组和对照组(P<0.05);而干预组血清Hcy水平较对照组明显降低(P<0.05),两组患者血压水平差异无统计学意义(P>0.05)。结论在常规降压的基础上口服叶酸及适量日光浴可显著降低H型老年高血压患者血压和血清Hcy水平,日光浴对H型老年高血压的防治有积极意义。

Objective To investigate the effect of folic acid and sun bath on the serum homocysteine（Hcy）and blood pressure level in elderly H-type hypertension.Methods One hundred and fifty cases of mild to moderate H-type hypertension were randomly divided into the control group,intervention group and combined group.The control group was given the routine treatment of hypertension;the intervention group was given oral Folic Acid Tablets 5 mg/d on the basis of conventional therapy and the combined group took 30 min sun bathing on the basis of oral Folic Acid Tablets 5mg/d and conventional anti-hypertensive therapy;the blood pressure and serum Hcy level in 3groups were measured before treatment and at 12 weeks after treatment.Results Compared with before treatment,the systolic and diastolic blood pressures after treatment in 3groups were significantly decreased（P〈0.05）,the serum level of Hcy in the intervention group and combined group were significantly decreased（P〈0.05）,while which in the control group had no significant change（P〉0.05）;in the comparison after 12-week treatment,the blood pressure and serum Hcy level in the combined group were significantly lower than those in the intervention group and the control group（P〈0.05）,while serum Hcy level in the intervention group was significantly decreased as compared with the control group（P〈0.05）,while no statistically significant difference in blood pressure levels was found between these two groups（P〉0.05）.Conclusion Oral folic acid and appropriate sun bath on the basis of routine anti-hypertension can significantly reduce blood pressure and serum Hcy levels in the elderly patients with H-type hypertension,and the sun bath has a positive significance for the prevention and treatment of H-type hypertension.