摘要
目的研究不同类型突发性聋患者外周血中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值的关系及各类型突聋的治疗效果,探讨高频突发性聋患者疗效较差原因。方法对2012年6月~2016年6月151例确诊为SHL患者的临床资料进行相关分析,对不同类型突发性聋患者听力损失平均阈值与其外周血中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值进行相关性分析;同时将不同类型患者疗效与全国SHL多中心前瞻性随机临床研究进行对比。结果全聋型、平坦型、高频下降型SHL患者的听力损失平均阈值与外周血血小板与淋巴细胞比值存在相关性(P<0.05)。低频下降型、高频下降型SHL患者的听力损失平均阈值与外周血中性粒细胞与淋巴细胞比值存在相关性(P<0.05)。高频下降型疗效较差(P<0.05)。结论不同类型突发性聋患者治疗方案应不同,疗效较差的高频下降型可考虑联合治疗。
Objective To study the relationship between neutrophil-to-lymphocyte ratio（NLR） and platelet-to-lymphocyte ratio （PLR） with different types of sudden hearing loss （SHL）, to investigate the causes of poor efficacy in patients with high frequency sudden deafness. Methods The clinical data of 151 patients diagnosed with SHL were retrospective analyzed from June 2012 to June 2016. Correlation research of mean threshold of hearing loss and neutrophils-to-lym- phocyte ratio and platelet-to-lymphocyte ratio in patients with different types of sudden deafness was analyzed. While the efficacy of different types of patients were compared with the national SHL multi-center prospective randomized clinical studies. Results The mean threshold of hearing loss of all deaf-type, fiat and high-frequency was relevant with PLR（P〈0.05）. The mean threshold of hearing loss of low-frequency and high＇frequency type was relevant with NLR （P〈0.05）. The effect of high-frequency type was poor（P〈0.05）. Conclusion The treatment of different type of SHL should not same, and high-frequency type SHL maybe should give a comprehensive treatment.
出处
《中国现代医生》
2017年第17期55-57,61,共4页
China Modern Doctor
