成骨细胞、破骨细胞与骨折愈合的相关性研究进展

Research progress on the correlation between osteoblasts, osteoclasts and fracture healing

骨折是骨科临床最常见的疾病,指骨的力学完整性丧失,同时也包括局部软组织与血管的损伤。骨折愈合是指对骨组织创伤局部的修复,是一个连续不断的过程,一面清除破坏,一面再生修复,其本质就是骨折断端发生的骨重建塑型过程。由成骨细胞主导的骨形成与由破骨细胞主导、成骨细胞和破骨细胞共同调控的骨吸收在骨重建过程中起重要作用,但有关两者与骨折愈合的关联性未见系统报道。本文以细胞生物学功能为出发点,从成骨细胞与破骨细胞对骨形成、骨吸收的影响入手对成骨/破骨细胞与骨折愈合的关联性做系统性综述。

Fracture is the most common disease in the orthopedics, the mechanical integrity of phalanx is lost, and the damage of local soft tissue and blood vessels is also included in fracture. Fracture healing refers to the local repair of bone tissue trauma, and is a continuous process, with removing the damage on the one hand and regeneration and repair on the other hand. Its essence is the bone reconstruction and plastic process occurred at fracture ends. Bone formation dominated by osteoblasts and bone resorption which is dominated by osteoclasts,co-regulated by osteoblasts,play an important role in bone remodeling. But the association between the two and bone healing is not reported. In this paper, the relationship between osteoblasts/osteoclasts and bone healing was systematically reviewed based on the influence of osteoblasts and osteoelasts on bone formation and bone resorption,with cell biology function as a starting point.