聚合物和卵磷脂纳米胶束递药系统的研究进展

Study Advance on Polymer and Phosphatidylcholine Nano-micelles Drug Delivery System

临床应用中,难溶性药物不仅会严重影响治疗效果,还可能会引起一系列的毒副作用,因此,难溶药物的递药系统成为研究的热点。纳米胶束系统就是目前最有效的递药系统之一,该系统主要由亲水性的外壳和疏水性的内核组成。纳米胶束作为一种纳米尺寸的递药系统具有许多独特的优势,如可有效避免血液循环中药物的提早释放,降低毒副作用、提高靶向性,进一步增加生物对难溶药物的利用度等优势,在难溶药物的递药系统中展现出良好的应用前景。综述了聚合物胶束和卵磷脂胶束的类别、构成、表征及其毒性和药代动力学检测方面的应用研究。

In clinical practice,the poorly water-soluble drugs will not only seriously affect the therapeutic effect,but also may causea series of toxic side-effects,therefore,delivery system for a poorly water-soluble drug has become a research hotpot. Nano-micelles systemis one of the most effective drug delivery systems,which mainly consists of the hydrophilic shell and hydrophobic core. Nano-micelles as anano-size drug delivery system presents many unique advantages,such as can effectively avoid the early-release of drug in blood circulation,reduce toxic side-effects and improve targeting,further increase the utilization of poorly soluble drug by organisms,etc.,showing promisingapplication prospect in drug delivery system for a poorly soluble drug. This review describes the category,constitute,characterization and itstoxicity and pharmacokinetics detection application of polymer and phosphatidylcholine nano-micelles.