骨膜蛋白在乳腺癌中的表达及临床意义

Expression and Clinical Significance of Periostin in Breast Cancer

目的探讨骨膜蛋白(PN)在乳腺癌组织及癌旁组织的表达及临床意义。方法选取临床确诊为乳腺癌的女性患者50例,采用免疫组化二步法,测定不同年龄、TNM分期、SBR分级、病理类型、是否伴有淋巴结转移等因素下,乳腺癌及癌旁组织中PN的高表达阳性率,并与正常乳腺组织中PN的表达进行比较。结果 PN在乳腺癌及癌旁组织间质中表达,并随着TNM分期(P=0.024)、SBR分级(P=0.012)及淋巴结转移(P=0.035)的变化,PN高表达阳性率升高;年龄、病理类型与PN的高表达阳性率无明显关联。结论乳腺癌中PN的高表达阳性率与TNM分期、SBR分级、淋巴结转移密切相关,并且参与乳腺癌的病理进展过程,PN可能成为潜在的乳腺癌监测指标。

Objective To investigate the expression and clinical significance of periostin （PN） in breast cancer and its adjacent tissues. Methotis We evaluated 50 women with breast cancer. We determined PN expression by immunohistoc, hemistry and analyzed positive expression in the tumors and adjacent tissue by patient age, TNM stage, SBR type, pathological type, lymph ncxle metasvasis, and other factors. Results PN expres- sion in breast cancer and cancer adjacent tissues was associated with an increase in TNM staging （P = 0.024）, SBR type （P ： 0.012）, and lymphatie metastasis （P = 0.035 ）, However, there was no significant correlation between age or pathological type （ P 〉 0.05 ）. Conclusion Expression of PN in breast cancer is associated with TNM staging, SBR type, and lymph node rnetastasis, and is involved in the pathological progression of breast cancer. PN may be a potential prognostic marker for breast cancer.