俄色叶提取物对小鼠急性酒精性肝损伤的保护作用

Hepatoprotective effects of Eseye extract on acute alcoholic liver damage in mice

目的:研究俄色叶提取物对小鼠酒精性肝损伤的保护作用。方法:采用体积分数为50%的乙醇一次性灌胃造成小鼠急性肝损伤,检测各组小鼠血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)、甘油三酯(TG)、低密度脂蛋白(LDL-C)的水平,及肝组织匀浆中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平的变化,同时HE染色观察肝脏组织学改变。结果:俄色叶提取物能不同程度地降低小鼠血清中ALT、AST、TG、LDL-C水平,减少肝匀浆MDA含量,升高肝匀浆SOD、GSH-Px的活性。病理切片显示各给药组小鼠肝组织损伤均有不同程度的减轻。结论:俄色叶提取物对小鼠急性酒精性肝损伤有一定的保护作用。

Objective：To investigate the hepatoprotective effects of Eseye extracts against alcohol-induced acute liver injury in mice.Method：The acute liver injury animal model was established in mice by alcohol garage（50% ）.The serum levels of ALT, AST,LDL-C and TG were determined. MDA, SOD and GSH-Px were detected in the liver homogenate, as well as the histopathological changes of the liver were observed by HE staining.Result ：Eseye extract decreased the levels of ALT,AST,TG and LDL-C in serum.Meanwhile,the MDA content in liver homogenate was reduced whereas the activity of SOD and GSH-Px were increased by Eseye extract.According to the liver histopathological observation, all of treatment groups showed alleviation in mice liver injury to varying degrees.Conclusion ：Eseye extract has protective effects on acute liver injury induced by alcohol in mice.