植物单体对肿瘤细胞血管生成拟态抑制作用的研究

The Research Progress about Plant Monomer on Angiogenesis Mimicry Inhibition of Tumor Cells

从植物单体方面对有效单体抑制肿瘤血管生成拟态(Vasculogenic mimicry,VM)的研究进展作一整理,总结了植物有效单体特定的作用机制与VM的相关性。VM是存在于恶性肿瘤细胞中一种新的肿瘤血供模式,在肿瘤的侵袭转移过程中起重要作用,但VM的作用机制是一个复杂的过程,需要寻找特异的靶点,特异性的抑制调控肿瘤VM。目前对植物单体抑制肿瘤细胞VM的研究仅处于初步研究阶段,已发现的有些植物单体通过基础实验证实疗效确切,具体的作用机制还需进一步研究。随着对VM研究方法的不断改进和理论的完善,植物单体抑制VM的研究必将受到越来越多的关注,对于实现植物有效单体现代化起到重要的意义。

VM is present in malignant cells, a new tumor blood supply mode, playing an important role in the invasion and metastasis of tumors, but the mechanism VM is a complex process that requires looking for specific targets, specific inhibition regulation of tumor VM. Advances from the plant effective monomer monomer aspects of inhibition of tumor angiogenesis mimicry （Vasculogenic mimicry, VM） to make a finishing plant effective monomer summarizes the specific mechanism of action and VM relevance. Current research on plant monomers inhibit tumor cell VM is only at the preliminary study stage, some plants have been found to confirm the efficacy of the monomer through the exact experimental basis,the specific mechanism of action needs further study. believing that with the improvement research VM, VM monomer plant continuous improvement of research methods and theories of suppression is bound to be more and more attention, for the realization of the modernization of the plant effective monomer play an important significance.