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骨代谢生化指标PINP,CTX,NTX与抗氧化应激酶在预测绝经期后女性髋部骨折中的意义 被引量:7

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摘要 探讨骨代谢生化指标I型前胶原氨基端前肽(PINP)、I型胶原C端肽(CTX)、I型胶原N端肽(NTX)与抗氧化应激酶在预测绝经期后女性髋部骨折中的意义。选取2015年1月~2016年7月珠海市香洲区人民医院和珠海市人民医院收治的的绝经后老年女性髋部骨折及体检人群共100例为研究对象,分为老年髋部骨折组(观察组,50例)及老年女性体检人群组(对照组,50例),对比两组血清PINP、CTX、NTX及SOD、CAT水平,分析PINP、CTX、NTX联合SOD、CAT预测髋部骨折的灵敏度、特异度、准确度及SOD、CAT与PINP、CTX、NTX的相关性。观察组PINP(56.34±1.86)ng/L、CTX(0.47±0.15)μg/L、NTX(0.43±0.11)μg/L较对照组高,观察组SOD(39.54±1.87)U/ml、CAT(26.43±1.87)U/ml低于对照组(P均<0.05);骨代谢生化指标及抗氧化应激酶联合预测髋部骨折的灵敏度为90.00%,特异度为86.00%,准确度为88.00%;相关性分析显示SOD、CAT均与PINP、CTX、NTX呈高度负相关(|r|均≥0.8,P均<0.05)。骨代谢生化指标PINP,CTX,NTX与抗氧化应激酶可为绝经期后女性髋部骨折的预防及早期诊断提供依据。
出处 《现代诊断与治疗》 CAS 2017年第10期1845-1847,共3页 Modern Diagnosis and Treatment
基金 2015年度珠海市医疗卫生科技计划项目(编号:2015A0004)
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