补肾养骨汤联合VAD方案对老年多发性骨髓瘤血清IL-6和VEGF水平的影响

The Influence of BuShen YangGu Tang Jointed with VAD Regimen on the Levels of Serum IL-6 and VEGF of Senile Patients with Multiple Myeloma

目的:探讨补肾养骨汤联合VAD方案对老年多发性骨髓瘤(Multiple Myeloma,MM)患者血清白介素6(IL-6)和血管内皮生长因子(VEGF)水平的影响。方法:采用随机数字表法将老年多发性骨髓瘤患者80例分为观察组和对照组各40例,对照组行VAD方案治疗,观察组行补肾养骨汤联合VAD方案治疗,观察2组治疗效果及治疗前后血清IL-6和VEGF水平、不良反应。结果:观察组总有效率为87.50%,明显高于对照组的62.50%(P=0.020);治疗后观察组血清IL-6和VEGF水平较对照组显著降低(P<0.01);不良反应发生率观察组为15.00%,低于对照组的37.50%(P=0.042)。结论:补肾养骨汤联合VAD方案治疗老年MM效果优于单纯VAD方案治疗,能降低血清IL-6和VEGF水平,而且安全可行。

Objective： To explore the influence of BuShen YangGu Tang jointed with VAD regimen on the levels of IL-6 and VEGF of senile patients with multiple myeloma （MM）. Methods： All 80 patients were divided into the observation group and the control group according to random number table method, 40 cases each group, the control group were performed VAD regimen, and the observation group accepted BuShen YangGu Tang jointed with VAD regimen. Adverse reaction, the levels of IL-6 and VEGF, therapeutic effects of both groups were observed be- fore and after the treating. Results： Total effective rate of the observation group was 87.50%, higher than 62.50% of the control group notably （P=-0.020）; the decrease of the levels of IL-6 and VEGF of the observation group was more signficant than that of the control group after treating notably （P〈0.01）; the incidence of adverse reaction of the ob- servation group was 15.00%, remarkably lower than 37.50% of the control group （P=-0.042）. Conclusion： Curative effects ofBuShen YangGu Tang jointed with VAD regimen are better than the effects of only VAD regimen in the treatment for senile patients with MM, and it could decrease the levels oflL-6 and VEGF, which is safe and practicable.