摘要
Non-coding RNAs （ncRNAs） are critical regulators of gene expression in essentially all life forms. Long ncRNAs （IncRNAs） and microRNAs （miRNAs） are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regard- ing regulatory roles of some key primate-specific lncRNAs and miRNAs.
Non-coding RNAs （ncRNAs） are critical regulators of gene expression in essentially all life forms. Long ncRNAs （IncRNAs） and microRNAs （miRNAs） are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regard- ing regulatory roles of some key primate-specific lncRNAs and miRNAs.
基金
supported by the National Basic Research Program of China(Grant No.2015CB943000)
the National Natural Science Foundation of China(Grant No.31471225)
the CAS Key Laboratory of Innate Immunity and Chronic Disease,China
the Fundamental Research Funds for the Central Universities of China(Grant No.WK2070000034)awarded to GS
