不同含漱液对白血病化疗所致口腔炎的疗效比较

Comparison of Different Gargle Effect on Leukemia Chemotherapy Induced Stomatitis

目的:观察复方黄芩含漱液、生物多糖抗菌含漱液以及生理盐水加庆大霉素含漱液对白血病化疗所导致的口腔炎的临床疗效。方法:随机选择2016年7月-2017年4月在本院进行化疗的白血病患者120例作为研究对象,按照随机数字表法将患者分为复方黄芩含漱液组(HQ组)、生物多糖抗菌含漱液组(SW组)、生理盐水加庆大霉素含漱液组(NS组),各40例。HQ组使用复方黄芩含漱液,SW组使用生物多糖抗菌含漱液,NS组用生理盐水500 m L加庆大霉素64万单位组成的漱口液漱口,从化疗前的第1天开始至化疗后14 d。观察三组患者口腔炎发生率、口腔炎愈合时间以及口腔炎发生程度。结果:HQ组患者口腔炎发病率为10.00%,明显低于SW组的20.00%,SW组发病率明显低于NS组45.00%,差异均有统计学意义(P<0.05)。HQ组患者口腔炎愈合时间明显短于SW组,SW组口腔愈合时间明显短于NS组,差异均有统计学意义(P<0.05)。HQ组口腔炎发病程度明显轻于SW组,SW组口腔炎发病程度明显轻于NS组,差异均有统计学意义(P<0.05)。结论:在白血病化疗所致口腔炎的防治中,复方黄芩含漱液效果较好,能够明显降低化疗期间口腔炎的发病率,缩短愈合时间,减轻发病程度,可临床推广应用。

Objective：To observe the clinical curative effect of Compound Scutellariae Gargle,Biological Polysaccharide Antibacterial Gargle and saline plus Gentamicin gargle on leukemia chemotherapy caused stomatitis.Method：120 patients with leukemia who were treated with chemotherapy in our hospital from July 2016 to April 2017 were randomly selected,patients were randomly divided into Compound Scutellariae Gargle group（HQ group）,Biological Polysaccharide Antibacterial Gargle group（SW group）and saline plus Gentamicin gargle（NS group）,40 cases in each group.HQ group used Compound Scutellaria gargle,SW group used Biological Polysaccharide Antibacterial Gargle,NS group used 500 m L saline plus 640 thousand units Gentamicin,from the first day before chemotherapy to 14 days after chemotherapy.The stomatitis rate,healing time and the occurrence degree of stomatitis in three groups were observed.Result：The stomatitis incidence rate of HQ group was 10.00%,which significantly lower than 20.00% of SW group,and the stomatitis incidence of SW group was significantly lower than 45.00% of NS group,the differences were statistically significant（P〈0.05）.The stomatitis healing time of HQ group was significantly shorter than that of the SW group,the stomatitis healing time of SW group was significantly shorter than that in the NS group,the differences were statistically significant（P〈0.05）.The incidence of stomatitis in HQ group was lighter than that in the SW group,the incidence of stomatitis in SW group was significantly lighter than that in NS group,the differences were statistically significant（P〈0.05）.Conclusion：In the prevention and treatment of leukemia chemotherapy induced stomatitis,better effect of Compound Scutellariae Gargle,can significantly reduce the incidence of stomatitis during chemotherapy,shorten healing time,reduce disease severity in clinical application.