摘要
Chronic infection with hepatitis B virus （HBV） is a major cause, ofcirrhosis and liver cancer worldwide. HBV is a smart DNA virus that replicates through an RNA intermediate. The viral genome translocates to the nucleus where it is converted into covalently closed circttlar DNA （cccDNA） serving as a template for viral transcription.
Chronic infection with hepatitis B virus （HBV） is a major cause, ofcirrhosis and liver cancer worldwide. HBV is a smart DNA virus that replicates through an RNA intermediate. The viral genome translocates to the nucleus where it is converted into covalently closed circttlar DNA （cccDNA） serving as a template for viral transcription.
