摘要
We previously used recombinant soluble gp41 （rsgp41） as a targetto screen a ntnnan oone marrow cul,~n library by the yeast two-hybrid assay, and we identified an HW-1 gp41-binding protein, human POB1 （the partner of RalBP1）. We found that the gp41- binding site was located at the C-term- inal region （aa462-521） of POB1 and the POBl-binding site was on the N-term- inal heptad repeat （NHR） region of HIV-1 gp41.
We previously used recombinant soluble gp41 （rsgp41） as a targetto screen a ntnnan oone marrow cul,~n library by the yeast two-hybrid assay, and we identified an HW-1 gp41-binding protein, human POB1 （the partner of RalBP1）. We found that the gp41- binding site was located at the C-term- inal region （aa462-521） of POB1 and the POBl-binding site was on the N-term- inal heptad repeat （NHR） region of HIV-1 gp41.
