丹红注射液对5-氟尿嘧啶心脏毒性保护作用的临床研究

Clinical research of prevention for 5-fluorouracil cardiotoxicity with Danhong injection

目的：观察丹红注射液对5-氟尿嘧啶相关心脏毒性的保护作用。方法：100例患者随机分为对照组及治疗组，治疗组50例，给予含5-氟尿嘧啶的FOLFOX4方案化疗的同时加用丹红注射液（丹红注射液＋5-氟尿嘧啶组），对照组50例，给予含5-氟尿嘧啶的FOLFOX4方案化疗（5-氟尿嘧啶组）。观察两组患者心电图，超声心动图中左心室舒张柬期内径（LVEDD）、左心室收缩末期内径（LVESD）、左室射血分数（LVEF）指标，心肌酶谱中磷酸肌酸激酶同工酶（CK—MB）、血清乳酸脱氢酶（LDH）的改变。结果：化疗后治疗组心电图异常改变率、LVEDD、LVESD、LVEF、CK—MB、LDH改变与对照组比较有显著性差异（P〈005）。结论：丹红注射液可以降低5-氟尿嘧啶药物所致的心脏毒性的发生率。

Objective ：To observe the protection of Danhong injection to prevent 5-fluorouracil related cardiactoxicity.Methods： All 100 patients were randomized into two groups,50 patients were in the treatment group and 50 patients were in the control group.Patients in the treatment group received Danhong injection starting one day before 5-fluorouracil based FOLFOX4 chemotherapy.50 patients in the control group received 5-fiuorouracil based FOLFOX/i chemotherap.Electrocardiogram, echocardiogram and enzyme were employed to evaluate the cardiac function.Results ： Compared with the control group,the adnomalities change rate of ECG and the change of LVEDD, LVESD, LVEF, CK-MB, LDH in the treatment group were significantly different （P 〈 0.05）.Conclusion： Danhonginjection can reduce the incidence ofcardiactoxicity induced by 5-fiuorouracil.