5-HTT转运体基因多态性与卒中后抑郁合并心血管疾病的相关性研究

Relationship between 5-HRRLPR polymorphism and post stroke depression

目的：探讨卒中后抑郁（post stroke depression，PSD）合并心血管疾病与5-HTT基因连锁多态区（5-HTTLPR）多态性的相关性。方法：从广西江滨医院神经内科住院的患者中按照入组标准筛选出卒中后抑郁合并心血管疾病患者186例作为研究组，选取同期住院的无抑郁的卒中合并心血管疾病患者186倒作为对照组。运用聚合酶链反应技术（PCR）检测两组5-HTTLPR多态性的等位基因（L和S）和基固型（SS，SL，LL）的分布频率。结果：基因型比较方面，PSD组5-HTTLPR短重复序列，短重复序列（Short／Short，SIS）基因型频率（40．32％）明显高与non—PSD组（24．19％），两者之间的差异具有显著性（P〈0．01）。等位基因比较方面，PSD组（short，S）频率（6613％）明显高于non—PSD组的（56．45％），两者之间的差异具有统计学意义（P〈0.01）。结论：5-HTTLPR中的SS基因型和S等位基因可能是卒中后抑郁的易感基因之一。

Objective ：To explore the relationship between 5-HRRLPR polymorphism and post stroke depression Methods： 186 posts stroke patients of neurology department of Guang Xi Jianghing hospital were selected as the study group according to the inclusion criteria ; 186 cases of non depressive stroke patients were selected as the control group, the Polymerase Chain Reaction was used to detect the frequency of genotype（SS,SL,LL） and allele（S,L） of both group. Results： As far as genotype is concerned, the frequency of short/short genotype in the PSD group （40.32%）is significantly higher than that of the non-PSD group（24.10%） （P 〈 0.01）;as for the frequency of the allele of both group. S allele frequency of the PSD group （66.13%） is significantly higher than that in the non-PSD group which is 56.45%. （P 〈 0.01）. Conclusions： genotype SS and S allele of 5-HTTLPR may be one of the risk genotype for post stroke depression.