贵阳市部分体检人群高尿酸血症与代谢综合征的相关性

Relativity between Hyperuricemia and Metabolic Syndrome in Partial Health Examination Population in Guiyang

目的:了解贵阳市部分成年体检人群中高尿酸血症(HUA)与代谢综合征(MS)的检出情况,探讨HUA与代谢综合征(MS)的相关性。方法:抽取体检中心进行医学体检的人群中具有完整体检资料13 444例作为研究对象,获取其身高、体重、血压、空腹血糖、血脂及血尿酸(BUA)等相关资料,分析HUA及MS在性别、年龄间的分布;以HUA发生为因变量,将年龄、性别、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)为自变量,进行多元Logistic回归分析;分析MS及其各组分与BUA水平。结果:HUA检出率为24.4%,MS检出率为15.2%;男性各项疾病检出率均高于女性(P<0.05);性别(男)、超重和(或)肥胖、高血压、血脂紊乱、高血糖是HUA的危险因素;年龄小于50岁是HUA的保护因素,超重、肥胖、高血糖、高血压、血脂紊乱及MS检出组的BUA水平均高于未检出组,差异均有统计学意义(P<0.05)。结论:贵阳市部分成年体检人群HUA及MS检出率均较高,且HUA与MS关系密切,BUA升高可能是MS发生的影响因素;BUA水平和MS的发生相关联,可考虑将其纳入MS的组分构成。

Objective： To understand the detection condition of metabolic syndrome（ MS） and hyperuricemia（ HUA） in partial health examination population in Guiyang and to explore the association between HUA and MS. Methods： 13 444 people with complete physical examination data were enrolled in this study who participated in the health examination in the Affiliated Hospital of Guizhou Medical University from 2011 June to 2012 July. The data of height,weight,blood pressure,fasting plasma glucose,blood lipids and blood uric acid was collected,and the distribution of HUA or MS in the gender and age was analyzed. The age,gender,BMI,SBP,DBP,TG,HDL-C and FPG were used as independent variable,and multivariate logistic regression analysis was performed with HUA as dependent variable. The comparison of BUA levels for MS and its components was analyzed. Results：The relevance ratio of HUA and MS were 24. 4% and 15. 2%,respectively,and the rates were higher in male than in female（ P〈0. 05）. Gende（ male）,overweight and（ or） obesity,high blood pressure,dyslipidemia,and hyperglycemia were the risk factors of HUA; less than 50-year-old people were the protective factor of HUA. The level of BUA in the MS groups,overweight（ obesity）,hypertension,dyslipidemia and hyperglycemia were respectively higher than not detected group; and the difference was statistically significant（ P〈0. 05）. Conclusion： The relevance ratio of HUA and MS in partial health examination population in Guiyang is higher. HUA and MS are associated. The Rising of BUA may be influence factor of MS. The level of BUA is associated with the occurrence of MS,and it can belong to the components of MS.