贵阳市40岁以上成年人不同糖耐量与心脑血管事件患病率的关系

The Relationship between Different Glucose Tolerance and the Prevalence of Cardio-cerebrovascular Events in Adults over the Age of 40 in Guiyang

目的:探讨贵阳市40岁以上成年人不同糖耐量水平与心脑血管事件患病率的关系。方法:贵阳市云岩区40岁以上居民10 022人,根据葡萄糖耐量试验结果,分为正常葡萄糖耐量(NGT)组、葡萄糖调节受损(IGR)组及糖尿病(DM)组,对3组人群进行问卷调查(基本资料、生活习惯及心脑血管疾病病史)、测量血压、计算体重指数及测定血脂及血糖指标,比较3组人群的心脑血管事件的患病率及其与心脑血管事件的关系。结果:NGT组、IGR组、DM组被调查对象心脑血管事件的患病率分别为2.09%、3.57%、6.22%,与NGT组相比差异具有统计学意义(P<0.01);Logistic回归分析显示,年龄、高血压、高2h PG为心脑血管事件的危险因素;DM组发生心脑血管事件的风险比为1.412(P=0.019,95%CI 1.058~1.894),IGR组发生心脑血管事件的风险与NGT组相比,差异无统计学意义(P=0.590)。结论:40岁以上IGR、DM人群较同龄NGT人群有着较高的心脑血管事件患病率,DM患者发生心脑血管疾病的风险明显增高。

Objective： To investigate the relationship between different glucose tolerance and the prevalence of cardio-cerebrovascular events among adults over the age of 40 in Guiyang. Methods：Questionnaires were conducted among 10 022 residents over the age of 40 in Yunyan district of Guiyang. According to 75 g oral glucose tolerance test,the 10 022 residents were divided into the normal glucose tolerance（ NGT） group,impaired glucose regulation（ IGR） group and diabetes mellitus（ DM） group,comparing the prevalences with the relationship of cardio-cerebrovascular events among the 3 groups. Results： The prevalences of cardio-cerebrovascular in groups NGT,IGR,and DM were respectively 2. 09%,3. 57% and 6. 22%,The later 2 were significantly different from that in NGT group（ P〈0. 01）. Logistic regression analysis showed that age,hypertension and high 2h PG,were the risk factors for cardio-cerebrovascular events; The cardio-cerebrovascular event risk ratio in DM group was 1. 412（ P = 0. 019,95% CI1. 058-1. 894）. Comparing the cardio-cerebrovascular event risk ratio between groups IGR and NGT,the difference was not statistically significant（ P = 0. 590）.Conclusion： For people over 40,IGR and DM populations have a higher prevalence of cardio-cerebrovascular events than NGT population,and the risk of diabetic patients with cardio-cerebrovascular events is significantly increased.