利拉鲁肽与胰岛素治疗2型糖尿病的疗效比较

Comparison of Curative Efficacy of Liraglutide and Insulin in the Treatment of Type 2 Diabetes

目的:比较利拉鲁肽与胰岛素治疗2型糖尿病患者的临床疗效。方法:选择2型糖尿病患者80例,随机分为观察组和对照组,观察组患者采用二甲双胍联合利拉鲁肽治疗,对照组患者接受二甲双胍及胰岛素治疗,均治疗3个月;比较两组治疗前后空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb Alc)、体重、体重指数(BMI)及腰围变化,比较治疗前后观察组空腹胰岛素(Fins)、胰岛素抵抗指数(HOMA-IR)及胰岛B细胞功能指数(HOMA-β),同时观察两组的不良反应发生率。结果:在治疗结束后,两组患者FPG、2h PG、Hb Alc水平、体重、体重指数(BMI)及腰围均低于治疗前(P<0.05),且观察组低于对照组(P<0.05);观察组患者在治疗后的Fins、HOMA-IR水平显著下降,HOMA-β水平明显提高,不良反应发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论:利拉鲁肽治疗2型糖尿病患者的临床疗效较好,相对安全性较高。

Objective： To compare the curative effect of liraglutide and insulin in treatment of patients with type 2 diabetes mellitus. Methods： Eighty cases of patients with type 2 diabetes were randomly divided into observation group and control group. Patients in observation group were treated with metformin combined with liraglutide for 3 months,patients in the control group received the treatment of insulin combined with metformin for 3 months. Fasting blood glucose（ FPG）,postprandial 2 h blood glucose（ 2h PG）,glycosylated hemoglobin（ Hb Alc）,weight,body mass index（ BMI） and waist circumference were compared between the two groups before and after treatment. The fasting insulin（ Fins）,insulin resistance index（ HOMA-IR） and the B cell function index（ HOMA-beta） of the observation group were compared before and after treatment,and the incidence of adverse reactions in the two groups was observed. Results： At the end of treatment,FPG,2h PG,Hb Alc level,body weight,body mass index（ BMI） and waist circumference of the two groups were lower than those before treatment（ P〈0. 05）,and after treatment,these indexes in observation group were lower than control group（ P〈0. 05）; after treatment,Fins and HOMA-IR of the patients in the observation group decreased significantly,HOMA-levels increased significantly,the incidence of adverse reactions in observation group was significantly lower than the control group,the differences were statistically significant（ P〈0. 05）. Conclusion： The curative efficacy of liraglutide the clinical efficacy of patientsn in the treatment of type 2 diabetes mellitus is good,and relatively safe.