丁苯酞对急性脑梗死患者NT-proBNP水平和血清炎症因子的影响

Effect of dl-3n-butylphthalide on NT-proBNP levels and inflammatory cytokines of patients with acute cerebral infarction

目的探讨分析丁苯酞对急性脑梗死患者NT-proBNP水平和血清炎症因子的影响。方法选择2014年3月—2016年5月在衡水市第五人民医院神经内科接受治疗的118例急性脑梗死患者,随机分为对照组60例和观察组58例。对照组给予常规药物治疗,观察组在对照组的基础上给予丁苯酞注射液治疗。观察治疗前及治疗7、14 d后两组患者的血浆N末端B型脑钠肽前体(NT-proBNP)水平、美国国立卫生研究院卒中量表(NIHSS)和血清炎症因子包括超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素-6(interleukin-6,IL-6)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α),以及不良反应发生情况。结果治疗前,两组患者的血浆NT-proBNP水平、NIHSS评分以及血清炎症因子水平比较差异无统计学意义。治疗7、14 d后,两组NT-proBNP水平、NIHSS评分均明显降低,与治疗前比较差异显著(P<0.05);治疗7、14 d后,观察组的NT-proBNP水平显著低于对照组(P<0.05);治疗14 d后,观察组的NIHSS评分显著低于对照组,比较差异具有统计学意义(P<0.05)。治疗前,两组的hs-CRP、IL-6、TNF-α比较差异无统计学意义;治疗7、14 d后,两组的hs-CRP、IL-6、TNF-α水平均明显降低,与治疗前比较差异显著(P<0.05);且观察组的以上3个血清炎症因子水平均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论丁苯酞可有效抑制急性脑梗死患者的血浆NT-proBNP水平及血清炎症因子水平,改善患者神经功能预后。

Objective To investigate the clinical efficacy of dl-3n-butylphthalide and its effect on NT-proBNP levels and inflammatory cytokines of patients with acute cerebral infarction.Methods Total 118 patients with acute cerebral infarction in Hengshui Fifth People＆#39;s Hospital were randomly divided into control group and observation group.Sixty patients in control group were treated with conventional medication,and 58 patients in observation group were treated with dl-3n-butylphthalide injection based on conventional medication.The NT-proBNP levels,score of neurological deficits （NIHSS）,inflammatory cytokines including hypersensitive C-reactive protein （hs-CRP）,interleukin-6 （IL-6）,and tumor necrosis factor-cα （TNF-α） before and after 7 and 14 d of treatment,and adverse reaction were observed and analyzed.Results Before treatment,differences in the NT-proBNP levels,NIHSS score,hs-CRP,IL-6,and TNF-α between two groups were not obvious.After 7 and 14 d of treatment,NT-proBNP levels in observation group were significantly lower than those in control group （P 〈 0.05）.And after treatment for 14 d,NIHSS score in observation group were conspicuously lower than those in control group （P 〈 0.05）.Additionally,the levels of hs-CRP,IL-6,and TNF-α in observation group were markedly lower than those in control group （P 〈 0.05）.Conclusion D1-3n-butylphthalide injection has a good ability in inhibiting NT-proBNP levels and inflammatory cytokines,and improves the neurological function of patients with acute cerebral infarction.