地榆烘法制炭前后止血作用比较

Comparison on hemostatic effect of Sanguisorbae Radix and charred Sanguisorbae Radix before and after baking

目的比较地榆烘法制炭前后的止血作用。方法昆明小鼠60只,随机分为6组:对照组,云南白药(阳性药,0.667 g/kg)组,地榆高、低剂量(8、2 g生药/kg)组,地榆炭高、低剂量(8、2 g生药/kg)组,每天ig给药1次,连续给药3 d,于末次给药1 h后检测小鼠出血时间、凝血时间,血凝仪检测凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT),进行血小板计数。结果与对照组比较,高剂量地榆和烘制的高、低剂量地榆炭显著缩短小鼠的出血时间、凝血时间、PT、TT和APTT;高、低剂量地榆和高剂量地榆炭显著提高血小板计数;与地榆高剂量组比较,高剂量地榆炭能显著缩短小鼠的PT、TT、出血和凝血时间,对血小板数量和APTT的影响差异不显著。结论地榆烘法制炭后止血作用增强。

Objective To compare the hemostasis effect of Sanguisorbae Radix （SR） and charred Sanguisorbae Radix （CSR） before and after baking.Methods Totally 60 Kunming mice were randomly divided into six groups：control group,Yunnan Baiyao （positive drug group,0.667 g/kg）,SR high and low dose （8,2 gcrude drug/kg） group,and CSR high and low dose （8,2 gcrude drug/kg） group.Mice were continuously ig with relatively drug once a day for 3 d.The bleeding time and clotting time were tested 1 h after the last administration,the prothrombin time （PT）,thrombin time （TT）,and activated partial thromboplastin time （APTT） were detected by blood coagulation analyzer,and the number of platelet was count.Results Compared with control group,SR of high dose,and CSR of high and low doses can obviously shorten the bleeding time,clotting time,PT,TT,and APTT.SR of high and low doses and CSR of high dose can elevate the blood platelets count.Compared with SR high dose group,CSR of high dose can obviously shorten the PT,TT,bleeding time,and clotting time,but could not be statistically significant on the blood platelets count and APTT.Conclusion SR and CSR have different hemostasis mechanisms,the function of hemostasis was more effective after charcoal by baking.