血栓通注射液联合单唾液酸四己糖神经节苷脂钠对脑梗死的疗效研究

Therapeutic effect of Xueshuantong Injection combined with Sodium Monosialotetrahexosylganglioside Injection on cerebral infarction

目的研究血栓通注射液联合单唾液酸四己糖神经节苷脂对脑梗死的治疗效果。方法选择2013年1月—2015年12月在新疆维吾尔自治区职业病医院进行诊治的脑梗死患者100例,随机分为两组。对照组静脉滴注血栓通注射液,研究组静脉滴注血栓通注射液及单唾液酸四己糖神经节苷脂,两组均治疗2周。比较两组的治疗效果,血清白介素-6、C反应蛋白水平,NIHSS评分、Barthel指数以及血液流变学变化。结果研究组的有效率为92.00%,明显高于对照组的70.00%,差异有统计学意义(P<0.05)。治疗后两组的血清白介素-6和C反应蛋白水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且研究组血清白介素-6和C反应蛋白水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组的NIHSS评分明显降低,Barthel指数明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且研究组明显优于对照组,差异有统计学意义(P<0.05)。治疗后两组的血小板聚集率和血黏稠度均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且研究组血小板聚集率和血黏稠度明显低于对照组,差异有统计学意义(P<0.05)。结论血栓通注射液联合单唾液酸四己糖神经节苷脂具有显著的治疗效果,可以明显改善脑梗死患者的炎症因子水平、神经功能、日常生活能力和血液流变学。

Objective To investigate the clinical effect of Xueshuantong Injection combined with Sodium Monosialotetrahexosylganglioside Injection on cerebral infarction.Methods Selected 100 cases of patients with cerebral infarction who were treated in Occupational Disease Hospital of Xinjiang Uygur Autonomous Region from January 2013 to December 2015,divided into two groups randomly.The observation group was treated with Xueshuantong Injection combined with Sodium Monosialotetrahexosylganglioside Injection,control group was treated with Xueshuantong Injection.The therapeutic effect,IL-6,C reactive protein level,NIHSS score,Barthel index and hemorheology were compared.Results The effective rate of observation group was 92.00%,significantly higher than the control group 70.00%,the difference was statistically significant （P 〈 0.05）.The level of serum IL-6 and C reactive protein were significantly decreased （P 〈 0.05）,and the observation group decreased more obviously,the difference was statistically significant （P 〈 0.05）.After treatment,NIHSS score of two groups decreased significantly,and Barthel index increased significantly （P 〈 0.05）,and the study group was significantly better than the control group,the difference was statistically significant （P 〈 0.05）.After treatment,platelet aggregation and blood viscosity were decreased significantly （P 〈 0.05）,and the observation group decreased more obviously,the difference was statistically significant （P 〈 0.05）.Conclusion Xueshuantong Injection combined with Sodium Monosialotetrahexosylganglioside Injection has significant therapeutic effect,can significantly improve the level of inflammatory factors,neural function,ability of daily life and blood rheology in patients with cerebral infarction.