全身麻醉药对蒽环类药物化疗后患者围手术期心脏影响

Perioperative cardiac risk of patient received anthracycline chemotherapy

背景 蒽环类药物因其良好的抗肿瘤特性被广泛应用于各类血液系统肿瘤及实体肿瘤、如淋巴瘤、软组织肿瘤、乳腺癌、胃癌、卵巢癌等.但在其应用于临床后不久即被报道出有严重的副作用,包括骨髓抑制以及致命性的心脏毒性. 目的 旨在探讨全身麻醉药对接受过蒽环类药物化疗后患者围手术期心脏功能的影响. 内容 综述用于乳癌新辅助化疗的蒽环类药的心脏毒性、蒽环类药物治疗后的患者围手术期心血管危险事件及心脏保护策略. 趋向 临床麻醉中应重视蒽环类药物本身对心肌细胞的影响,合理用药和管理,减少围术期对蒽环类药物治疗后的患者的影响,降低其围手术期心血管危险事件发生率.

Background Anthracyclines are one of the most effective anti-tumors antibiotics and they are widely used in hematologic and solid tumors like lymphoma,soft-tissue tumor,gastric cancer,breast cancer and ovarian cancer.But it was reported to have serious side-effects including cardiotoxicity of myocardium and myelosuppression after the first use.Objective This review is aim to discuss the cardiotoxity of general anesthetics in anthracycline exposed patient during perioperative period.Content The cardiotoxity after anthracycline neoadjuvant chemotherapy,perioperative cardiaovascular events after anthracycline chemotherapy and its protect strategy.Trend The cardiotoxity after anthracycline chemotherapy should take into account to reduce the cardiovascular events in clinical anesthesiology.