吗啡联合羟考酮应用于术后镇痛的临床研究

Clinical research of morphine combined with oxycodone in postoperative pain management

背景 阿片类药物被广泛用于缓解中重度急慢性疼痛,但其副作用限制了阿片类药物的应用,需探索新的给药模式以减少副作用,改善镇痛效果. 目的 概述吗啡联合羟考酮在术后镇痛中的有效性及安全性,为临床应用和进一步研究提供参考. 内容 吗啡联合羟考酮可获得更好的镇痛效果,副作用也减少. 趋向 吗啡联合羟考酮在术后镇痛中的应用具有诸多优势,但最佳方案仍需进一步临床研究.

Background Opioids are widely used for relief of moderate or severe acute and chronic pain.However,their utility is often limited by excessive adverse effects.New modality aimed to reduce adverse effects and improve analgesia are therefore required.Objective Summarizing the efficacy and safety of morphine plus oxycodone in the treatment of postoperative pain and providing evidence for its clinical application and further studies.Content The combination of morphine and oxycodone may result in enhanced analgesia and fewer adverse events in the management of postoperative pain.Trend Although the co-administration of morphine and oxycodone has been proved to possess many advantages in pain management,the best regimen still needs further clinical studies.