利血平致抑郁样啮齿类动物模型的研究进展

The Research Progress of Depression-like Rodent Models by Reserpine

抑郁症是一种高患病率、高致残率、且有自杀倾向的慢性精神疾病,主要表现为情绪低落、悲观绝望等,严重者可影响个人日常生活。目前,随着对抑郁症研究的深入,抑郁症动物模型被广泛应用于实验研究。其中,利血平致抑郁样模型可以复制抑郁症的某些病理特征,该方法操作简便易行,可用于药物的初筛。本文综述了国内、外对利血平致抑郁样动物模型的相关研究,从该动物模型的一般情况、行为学、神经系统、免疫系统等方面的变化,分析该模型的特点、适用性及局限性,为研究人员应用利血平致抑郁样动物模型提供借鉴。

Depression is a high prevalence, morbidity, and suicidal chronic mental illness, which symptoms are pessimism and despair, severe cases can affect their daily life. At present, with the deepening of the research on depression, depression animal models are widely used in experimental studies. Among them, the reserpine-induced depression-like model can be replicated in some pathological features of depression. This paper reviews the reserpine-induced depression-like animal model studies, by observing the general situation, the behavior, neural system, immune system, analyzing the characteristics, applicability and limitations of the model, providing a reference model for the researchers who used reserpine depression-like model.