盐酸哌甲酯控释片联合卡马西平治疗伴中央颞区棘波的小儿良性癫痫合并多动综合征的疗效

Effects of osmotic-release oral system methylphenidate combined with carbamazepine in the treatment of children with benign epilepsy with centrotemporal spikes complicated with attention deficit hyperactivity disorder

目的探讨盐酸哌甲酯控释片(OROS-MPH)联合卡马西平治疗伴中央-颞区棘波良性癫痫(BECTs)合并多动综合征(ADHD)患儿的疗效。方法将BECTs合并ADHD患儿84例随机分为观察组与对照组各42例。两组均接受卡马西平治疗,6个月内脑电图(EEG)稳定后分别加心理行为治疗和心理行为联合OROS-MPH治疗。比较两组临床疗效及不良反应。结果观察组的BECTs总有效率为90.48%,与对照组的92.86%比较差异无统计学意义(P>0.05);观察组的ADHD总有效率为95.24%,显著高于对照组的64.29%(P<0.05);治疗后观察组的PSQ量表评分显著低于对照组(P<0.05)。结论 OROS-MPH联合卡马西平治疗BECTs合并ADH安全可靠,能够有效改善患儿的临床症状。

Objective To investigate the efficacy of osmotic-release oral methylphenidate （OROS-MPH） bined with carbamazepine in the treatment of children with benign epilepsy with centrotemporal spikes （ BECTs ） complicated with attention deficit hyperactivity disorder （ ADHD ） . Methods 84 cases of children with BECTs complicated with ADHD were randomly divided into observation group and control group, 42 cases in each group. Both groups received carbamazepine treatment for 6 months, then received psychological behavior or psychological behavior combined with OROS-MPH treatment respectively after the stabilization of electroencephalogram （ EEG ） within 6 months. The Parent Symptom Questionnaire of Conner Children＇s Behavior Questionnaire （ PSQ ） were evaluated before and after treatment. Results There were no significant deference in total effective rate of BECTs between the observation group （90.48 % ） and the control group （92.86 % ）（P〉 0.05 ）. The total effective rate of ADHD was 95.24 % in the observation group, which were significantly higher than that （64.29 % ） in the control group （P〈 0.05 ）. After treatment, the scores of PSQ in the observation group was significantly lower than those in the control group （ P〈0.05 ） . Conclusion OROS-MPH combined with carbamazepine in the treatment of BECTs complicated with ADH is safe and reliable, which can effectively improve the clinical symptoms of patients.