西酞普兰对慢性心力衰竭合并抑郁患者近、远期预后的影响

The influence of citalopram on short and long-term prognosis in patients with chronic heart failure complicated with depression

目的探讨西酞普兰对慢性心力衰竭(CHF)合并抑郁患者近、远期疗效的影响。方法将120例CHF合并抑郁患者根据用药方法分为两组:对照组(n=60)予以常规抗心衰治疗,观察组(n=60)在对照组基础上加用西酞普兰治疗,疗程6个月。比较两组临床疗效、治疗前后心功能、汉密尔顿抑郁量表(HAMD)评分,随访统计心衰加重再住院率及全因死亡率。结果观察组的总有效率为90.00%,显著高于对照组的78.33%(P<0.05);治疗后,观察组的HAMD评分、左室舒张末期内径(LVEDD)著低于对照组(P<0.05),左心室射血分数(LVEF)、6min步行距离(6WMT)显著高于对照组(P<0.05);随访期间,观察组心衰加重再入院率、全因死亡率分别为38.89%、9.26%,显著低于对照组的76.36%、21.82%(P<0.05)。结论西酞普兰辅助治疗CHF近期疗效确切,能够改善患者的抑郁症状及生活质量,从而改善心功能及远期预后。

Objective To evaluate the influence of citalopram on short and long-term prognosis in patients with chronic heart failure （CHF） complicated with depression. Methods 120 patients with CHF complicated with depression were divided into two groups according to the therapy method： Patients in the control group （n =60） received conventional anti-heart failure treatment, patients in the observation group （ n =60 ） received citalopram treatment on the basis of control group for 6 months. The clinical effect, heart function, Hamilton Depression Scale （HAMD） score before and after treatment were compared between the two groups, the re-admission and all-cause mortality were counted. Results The total effective rate of observation group was 90.00 %, significantly higher than 78.33 % of control group （ P〈0.05 ）; After treatment, the HAMD score, Left Ventricular End Diameter Diastolic （ LVEDD ） in observation group were significantly lower than those in the control group （ P〈 0.05 ）, while the Left Ventricular Ejection Fraction （ LVEF ） and 6rain Walking Distance （ 6 WMT ） were significantly higher than those in the control group （P〈0.05）; At the end of the follow-up period, the re-admission and all-cause mortality were 38.89 % and 9.26 % of observation group respectively, significantly lower than 76.36 %, 21.82 % of control group （P〈0.05） . Conclusion The short- term efficacy of citalopram in the treatment of CHF complicated with depression is obviously, it also can improve cardiac function and long - term prognosis.