乳腺癌根治术后疾病不确定感、抑郁和焦虑情绪与25-(OH)维生素D水平的关系

Association among 25-hydroxyvitamin D,postoperative disease uncertainty,depression and anxiety in patients after radical mastectomy

目的探讨血清25羟基维生素D[25-(OH)D]与乳腺癌根治术后疾病不确定感、抑郁、焦虑情绪的关系。方法收集62例乳腺癌根治术患者为观察组,同期健康体检者40例为对照组。比较两组Mishel疾病不确定量表(MUIS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分及血清25-(OH)D水平。结果观察组的MUIS各维度评分、HAMA、HAMD评分均显著高于对照组,血清25-(OH)D水平显著低于对照组(P<0.05);血清25-(OH)D水平与MIUS、HAMA、HAMD评分呈显著负相关性(r=-0.398、-0.498、-0.421,P<0.05)。结论乳腺癌根治术患者术后普遍存在疾病不确定感及焦虑抑郁情绪,且其与低血清25-(OH)D水平密切相关。

Objective To investigate the association among 25-hydroxyvitamin D 1 25- （ OH ） D 1, postoperative disease uncertainty, depression and anxiety in patients after radical mastectomy. Methods 62 patients after radical mastectomy were enrolled as observation group, while 40 healthy volunteers as control group. The scores of Mishel＇ s Disease Uncertainty Scale （ MUIS ）, Hamilton Anxiety Scale （ HAMA ）, Hamilton Depression Scale （ HAMD ） and the serum level of 25- （ OH ） D were compared between the two groups. Results The scores of various dimen- sions of MIUS, HAMA, HAMD in observation group was significantly higher than those in control group （ P〈0.05 ）, and the 25- （ OH ） D level in observation group was significantly lower than that in the control group （ P〈0.05 ）; The serum level of 25- （ OH ） D was significantly negatively correlated with the scores of MIUS, HAMA and HAMD （ r=-0.398, -0.498, -0.421; P〈0.05 ） . Conclusion Disease uncertainty, anxiety and depression are very common in patients after radical mastectomy, and they were significantly associated with lower serum level of 25- （ OH ） D.