精酮合剂对小鼠的抗疲劳作用

Anti-fatigue effect of L-arginine-α-ketoglutarate on mice

通过观察小鼠负重力竭游泳时间探讨精氨酸-酮戊二酸盐(精酮合剂,AAKG)对小鼠的抗疲劳作用,分别测定小鼠游泳前后血清尿素含量、肝糖原含量、全血乳酸含量等指标以探讨AAKG抗疲劳机制。结果表明,经AAKG处理过的小鼠负重游泳时间(4.71±1.36min)比对照组小鼠(3.01±0.46min)明显延长(P<0.05),AAKG组小鼠血清尿素氮含量(177.94±17.7mg/L)明显低于对照组(202.38±8.95mg/L)(P<0.05),AAKG组小鼠乳酸曲线下面积(85.88±9.74mmol/L)也显著低于对照组(112.82±17.10mmol/L)(P<0.05),而AAKG组小鼠肝糖原含量(11.95±0.35mg/g)显著性高于对照组小鼠(8.42±0.97mg/g)(P<0.05)。本实验结果表明AAKG具有较好的抗疲劳作用,推测与其能够提高小鼠代谢能力和增强应激能力有关。

The anti-fatigue effect of L-arginine-α-ketoglutarate（AAKG）was studied through weight loading swimming test on mice.Compared with control group（3.01±0.46min）,the swimming time of AAKG group was significantly increased（4.71±1.36 min）（P0.05）.Meanwhile,the production of serum urea（202.38±8.95mg/L for control group and 177.94±17.7mg/L for AAKG group）as well as the area under curve of serum lactic acid（112.82±17.10mmol/L for control group and 85.88±9.74mmol/L for AAKG group）were decreased while the content of glycogen（8.42±0.97mg/g for control group and 11.95±0.35mg/L for AAKG group）was increased significantly（P0.05）.The anti-fatigue effect of AAKG was obviously observed in mice,which might be related to the enhanced metabolic capacity and stress ability.