儿童肺炎支原体肺炎凝血功能和免疫功能相关指标水平变化及其临床意义

The Level Change of Coagulation Function and Immunologic Function Indexes in Children with Mycoplasma Pneumoniae Pneumonia and Its Clinical Significance

目的:分析肺炎支原体肺炎患儿凝血功能和免疫功能相关指标水平变化情况。方法:选取我院收治的肺炎支原体肺炎患儿100例,根据肺炎性质分为间质组(55例)和大叶组(45例),并选取正常健康儿童50例作为对照组,分别检测PT、APTT、TT、PTA、INR等相关凝血指标及IgM、IgG、IgA、C_3、C_4等相关免疫指标,观察其变化情况。结果:间质组和大叶组其PT、APTT时间均显著短于对照组(P<0.05);三组患儿TT、PTA、INR差异无统计学意义(P>0.05);间质组和大叶组其各项免疫学指标水平均显著低于对照组(P<0.05)。结论:肺炎支原体肺炎患儿的凝血和免疫功能均存在一定程度异常,对临床诊治该病有重要的指导意义.

Objective： To analyze the level change status of coagulation function and immunologic function indexes in children with mycoplasma pneumoniae pneumonia. Methods： Selected 100 cases of children with mycoplasma pneumoniae pneumonia and divided into interstitial group （55 cases） and lobar group （45 cases）, and selected 50 healthy children as control group, of whom the coagulation function indexes of PT, APTT, TT, PTA, INR and immunologic function indexes of IgM, IgG, IgA, C3, C, were detected and observed their change. Results： The PT and APTT of inter- stitial group and lobar group were significantly shorter than those of control group （P〈0.05）, the differences of TT, PTA and INR among three groups had no statistical significance （P〉0.05）; every immunologic function index level of interstitial group and lobar group was significantly lower than that of control group （P〈0.05）. Conclusion： There is a certain degree of abnormality in coagulation and immunologic function of children with myco- plasma pneumoniae pneumonia, which has directive importance to the diagnosis and treatment of this disease.