HMGA1和HMGA2在胰腺癌中的表达及其对预后的影响

Prognostic significance of HMGA1 and HMGA2 proteins expressions in pancreatic carcinoma

目的探讨高迁移率族蛋白A1（HMGA1）、高迁移率族蛋白A2（HMGA2）在胰腺癌组织中的表达及其对预后的影响。方法采用免疫组织化学SP法检测60例胰腺癌组织和30例正常胰腺组织中的HMGA1、HMGA2表达,并分析两者与胰腺癌预后的关系。结果胰腺癌组织中HMGA1和HMGA2的表达均显著高于正常胰腺组织,其阳性表达率分别为70.0%∶6.7%和73.3%∶3.3%，差异均有统计学意义（χ2=32.105,P=0.000；χ2=39.200，P=0.000）。HMGA1的表达强度与胰腺癌的组织学分级（χ2=6.774，P=0.034）、TNM分期（χ2=4.776，P=0.029）、淋巴结转移情况（χ2=12.614，P=0.000）相关；HMGA2的表达强度与胰腺癌的组织学分级（χ2=8.200，P=0.017）及TNM分期（χ2=7.253，P=0.007）相关。HMGA1和HMGA2的表达呈正相关（r=0.393，P=0.001）。KaplanMeier生存分析显示HMGA1阳性和HMGA2阳性患者的中位生存时间均较阴性患者短（14.0个月∶24.0个月，χ2=14.568，P=0.000；15.0个月∶21.0个月，χ2=7.270，P=0.007）。结论HMGA1、HMGA2在胰腺癌组织中高表达，二者在胰腺癌的发生、发展过程中具有协同作用,共同促进胰腺癌的侵袭和转移，联合检测HMGA1、HMGA2对预测胰腺癌的预后具有一定价值。

ObjectiveTo study the expressions and prognostic significance of high mobility group protein A1 （HMGA1） and high mobility group protein A2 （HMGA2） in pancreatic carcinoma. MethodsThe expressions of HMGA1 and HMGA2 were examined by immunohistochemical SP method in 60 cases of pancreatic carcinoma and 30 cases of normal pancreatic tissues. The relationship between the expression and prognosis was also analyzed. ResultsThe expressions of HMGA1 and HMGA2 in pancreatic carcinoma were significantly higher than those in normal tissues, and the positive expression rates were 70.0% vs. 6.7% （χ2=32.105,P=0.000） and 73.3% vs. 3.3%（χ2=39.200,P=0.000）. The expression of HMGA1 in pancreatic carcinoma was correlated with histological grade （χ2=6.774,P=0.034）, TNM stage （χ2=4.776,P=0.029） and lymphatic metastasis （χ2=12.614,P=0.000）. The expression of HMGA2 in pancreatic carcinoma was correlated with histological grade （χ2=8.200,P=0.017） and TNM stage （χ2=7.253,P=0.007）. The expression of HMGA1 was positively associated with HMGA2 expression（r=0.393,P=0.001）. KaplanMeier analysis showed that the median survival time of HMGA1 and HMGA2 positive patients were shorter than those patients with HMGA1 negative and HMGA2 negative （14.0 months vs. 24.0 months, χ2=14.568,P=0.000;15.0 months vs. 21.0 months, χ2=7.270,P=0.007）. ConclusionHMGA1 and HMGA2 are highly expressed in pancreatic carcinoma, and play synergistic roles in the generation and progress of pancreatic carcinoma. There is certain value of combined detection of HMGA1 and HMGA2 to predict the prognosis of pancreatic carcinoma.