Diekkopf-1相关肿瘤转移研究进展

Research progress of Dickkopf-1 related tumor metastasis

作为一种分泌型糖蛋白，Dickkopf-1（DKK1）与肿瘤转移关系密切，在肿瘤中高表达或低表达，其异常高表达促进肝癌、胃癌、非小细胞肺癌和乳腺癌等多种恶性肿瘤的转移。最新研究发现，DKK1与肿瘤的潜在转移关系密切。

As a secreted glycoprotein, Dickkopf-1 （ DKK1 ） is closely related to tumor metastasis, and it is highly or lowly expressed in tumor. The high expression of DKK1 promotes the metastasis of a variety of malignant tumors including liver cancer, gastric cancer, non-small cell lung cancer and breast cancer. Recent studies have found that DKK1 is inextricably bound up with the latent metastasis of tumor.