光催化烯烃加成/环化合成含氟异喹啉-1,3-二酮

Synthesis of Fluorinated Isoquinoline-1,3-Dione via Light-Catalysis Addition and Cyclization of Alkenes

发展了一种光催化活泼烯烃加成/环化合成含氟异喹啉-1,3-二酮的反应.在可见光催化下,多种N-烷基-N-甲基丙烯酰基苯甲酰胺衍生物与全氟碘代丁烷、溴二氟乙酸乙酯发生自由基串联加成环化反应,以67%~80%的产率合成了一系列具有潜在生理活性的含氟取代异喹啉-1,3-二酮衍生物.这为具有潜在药用价值的氟取代异喹啉-1,3-二酮的合成提供了一条绿色、高效、条件温和的途径.

A synthesis of fluorinated isoquinoline-1,3-diones via light catalyzing activated alkenes addition reaction was developed.Through light catalysis,various N-alkyl-N-methacryloylbenamides derivatives underwent radical cascade addition cyclization reaction with perfluorobutyliodide and ethyl bromodifluoroacetate.A series of fluorinated isoquinoline-1,3-diones derivatives with potential physiological activity was compounded in 67%~80% yields.This study provides a green efficient approach to afford fluorinated isoquinoline-1,3-dione under mild conditions.